Product Informations
Artemisinin is a medicine with the best effect in the treatment of malaria. It is a sesquiterpene lactone with peroxide group extracted from Artemisia annua. It has the characteristics of high efficiency, quick effect, clearing heat and relieving summer heat, reducing deficiency heat, killing protozoa and low toxicity. At present, the efficacy of artemisinin based combined therapy (ACT) for the treatment of malaria has reached more than 90% all over the world. It has been widely used in the treatment of malaria all over the world.
1、 Function
1. Anti malaria
Malaria (commonly known as pendulum cold and fever disease) is an insect borne infectious disease. It is an infectious disease caused by the bite of human body infected by Plasmodium. It can appear hepatosplenomegaly and anemia after repeated attacks for a long time. Artemisinin has contributed to the treatment of malaria to a certain extent. The peroxide bond in the structure of artemisinin is oxidizing and is an essential group for malaria resistance. The mechanism of action is that the free group produced by artemisinin in vivo binds to Plasmodium falciparum protein and changes the cell membrane structure of Plasmodium falciparum. After the free radicals combine with the Plasmodium protein, the bilayer membrane of mitochondria will swell and crack, and finally fall off, resulting in the destruction of the cell structure and function of Plasmodium, and the chromatin in the nucleus will also be affected to some extent.
2. Antitumor
Malignant tumor is the first killer endangering human health. If it is not treated in time, it will endanger life safety. In vitro experiments showed that a certain dose of artemisinin could induce apoptosis of many kinds of cancer cells, such as hepatoma cells, breast cancer cells, cervical cancer cells and so on, and significantly inhibit the growth of cancer cells. It is found that artemisinin can regulate the expression of cyclin in tumor cells, enhance the effect of CKIs and lead to tumor cell cycle arrest; Or lead to apoptosis and inhibit tumor angiogenesis to resist the occurrence and development of tumor. Artemisinin is used to treat leukemia by acting on the cell membrane of leukemia cells, increasing the permeability of the membrane and changing the osmotic pressure, resulting in the increase of calcium concentration in the cells, so as to activate calpain, make its cell membrane swell and crack, accelerate the release of apoptotic substances and increase the speed of apoptosis.
3. Treatment of pulmonary hypertension
Pulmonary hypertension (PAH) is a pathophysiological state characterized by pulmonary artery remodeling and the rise of pulmonary artery pressure to a certain limit. It can be a complication or syndrome. Artemisinin is used to treat pulmonary hypertension: it can reduce pulmonary artery pressure and improve symptoms in patients with PAH by relaxing blood vessels. Zaiman et al. Found that artemisinin has anti-inflammatory effect. Artemisinin and its core substances can inhibit a variety of inflammatory factors, and can also inhibit the production of nitric oxide by inflammatory mediators; Artemisinin has immunomodulatory effect; Feng Yibai and others found that artemisinin can inhibit the proliferation of vascular endothelial cells and vascular smooth muscle cells, and then play an important role in the treatment of PAH; Artemisinin can inhibit the activity of matrix metalloproteinases, thereby inhibiting pulmonary vascular remodeling; Artemisinin can inhibit the expression of PAH related cytokines and further enhance the anti vascular remodeling effect of artemisinin.
4. Immune regulation
It is found that the dosage of artemisinin and its derivatives can better inhibit T lymphocyte mitogen and induce the proliferation of mouse spleen lymphocytes without cytotoxicity. This finding has a good reference value for the treatment of T lymphocyte mediated autoimmune diseases. Artemisia annua glass vinegar can enhance nonspecific immunity and improve the total complement activity of mouse serum. Dihydroartemisinin can directly inhibit the proliferation of B lymphocytes, reduce the secretion of autoantibodies by B lymphocytes, reduce humoral immune response, inhibit humoral immunity and reduce the formation of immune complexes.
5. Antifungal
The antifungal effect of artemisinin also makes artemisinin show certain antibacterial activity. The research confirmed that the residue powder and water decoction of artemisinin had strong antibacterial effects on anthrax, Staphylococcus epidermidis, catarrhalis and diphtheria, and also had certain antibacterial effects on tuberculosis, Pseudomonas aeruginosa, Staphylococcus aureus and dysentery bacilli.
2、 Application field
Artemisia annua is used as an antimalarial drug. Its clinical application has proved that artemisinin and its derivatives have special effects on Plasmodium falciparum and Plasmodium falciparum, especially Artemisia annua a, which has a stronger effect than other artemisinin drugs on killing the intracellular clones of Plasmodium falciparum.
Product Parameters
| COMPANY PROFILE | |
| Product Name | Artemisinin |
| CAS | 63968-64-9 |
| Chemical Formula | C15H22O5 |
| Brand | Hande |
| Manufacturer | Yunnan Hande Bio-Tech Co., Ltd. |
| Country | Kunming, China |
| Established | 1993 |
| BASIC INFORMATION | |
| Synonyms | 3,12-epoxy-12h-pyranol(4,3-j)-1,2-benzodioxepin-10(3h)-one,octahydro-3,6,9-tri;artemisiaannual.,extract;huanghuahaosu;octahydro-3,6,9-trimethyl-3,12-epoxy-12h-pyrano(4,3-j)-1,2-benzodioxepin-10(;qinghausau;qinghausu;
QHS; ARTEMISININ99% |
| Structure |  |
| Weight | 282.34 |
| HS Code | N/A |
| Quality Specification | Company Specification |
| Certificates | N/A |
| Assay | Customized according to customer needs |
| Appearance | Colorless acicular crystal |
| Method of Extraction | Artemisia annua |
| Annual Capability | Customized according to customer needs |
| Package | Customized according to customer needs |
| Test Method | N/A |
| Logistics | Multiple transports |
| Payment Terms | T/T, D/P, D/A |
| Other | Accept customer audit all the time; Assist clients with regulatory registration. |
Hande product statement
1.All products sold by the company are semi-finished raw materials. The products are mainly aimed at manufacturers with production qualifications, and raw materials are not final products.
2.The potential efficacy and applications involved in the introduction are all from the published literature. Individuals do not recommend direct use, and individual purchases are refused.
3.The pictures and product information on this website are for reference only, and the actual product shall prevail.
