Paclitaxel is a new anti microtubule drug,which is widely used in clinical treatment of ovarian cancer,breast cancer,lung cancer,head and neck tumors,esophageal cancer,gastric cancer and soft tissue sarcoma.In recent years,albumin bound taxol has been developed through continuous exploration of taxanes and continuous improvement of preparation technology.Let’s take a look at the characteristics of Albumin-bound paclitaxel.
Albumin-bound paclitaxel:nanoparticles made of paclitaxel and human serum albumin by high-pressure vibration technology,one albumin molecule and seven paclitaxel molecules are combined,and the role of the albumin receptor Gp60 on the cell membrane and the cysteine rich acidic secretory albumen(SPARC)in the tumor tissue is used to promote the drug to enter the tumor cells and increase the chemotherapy effect.
1、Security
Albumin-bound paclitaxel:no cosolvent polyoxyethyl castor oil is required,which can safely increase the dose of paclitaxel,shorten the infusion time,and no pretreatment is required.
2、Pretreatment
Albumin-bound paclitaxel does not require pretreatment to prevent allergic reaction before administration.
3、Adverse reactions
Albumin-bound paclitaxel and paclitaxel liposomes:Due to the improvement of preparation technology,there is no need to add excipients such as polyoxyethyl castor oil,polysorbate 80,absolute ethanol,etc.,and the drug safety has been greatly improved.
4、Indications
Albumin-bound paclitaxel:relevant literature reports that its single drug and combination regimen is a treatment option for refractory advanced breast cancer that progresses rapidly or fails in multi line treatment.It also shows certain efficacy for paclitaxel and advanced triple negative breast cancer that have been previously treated with paclitaxel,and the side effects are tolerable.
Note:The potential efficacy and applications introduced in this article are all from published literature.
Yunnan Hande Biotechnology Co.,Ltd has been specializing in the production of paclitaxel API for more than 20 years,and is one of the world’s independent manufacturers of paclitaxel API,a plant-derived anti-cancer drug,approved by the US FDA,European EDQM,Australian TGA,Chinese CFDA,India,Japan and other national regulatory agencies.Hande can provide not only high-quality paclitaxel raw materials,but also technical upgrade services related to paclitaxel formulation.For more information,please feel free to contact us at 18187887160.
Post time: Dec-29-2022