Differences between paclitaxel injection and albumin-bound paclitaxel

The difference between paclitaxel injection and albumin-bound paclitaxel lies in the composition. Ordinary paclitaxel and albumin paclitaxel are actually the same kinds of drugs. Albumin paclitaxel, in which an albumin carrier is added,is essentially paclitaxel. By making albumin and paclitaxel into nanoparticles through high-pressure vibration technology, it can promote the drug to enter brain tumor cells after use, and enhance the effect of chemotherapy. Ordinary paclitaxel is an anti-cancer injection drug extracted from Taxus Chinensis.

Differences between paclitaxel injection and albumin-bound paclitaxel

Differences between paclitaxel injection and albumin-bound paclitaxel

1. Different effects

Paclitaxel injection needs to be pretreated with hormones and antihistamines, and the infusion time is long; Albumin paclitaxel combines the drug with human serum albumin by using nanotechnology, which greatly improves the solubility of the drug without using excipients. The infusion time is short, and the drug concentration at the tumor site is increased, so the effect is better.

2. Different probability of allergic reaction

Ordinary paclitaxel is highly lipophilic and insoluble in water. The injection needs anhydrous ethanol, castor oil and other excipients to help it dissolve. These excipients are more likely to cause allergic reactions; Albumin paclitaxel does not require pretreatment or excipients before use, so it is not easy to sensitize.

Note: The potential efficacy and applications introduced in this article are all from published literature.

Yunnan Hande Biotechnology Co., Ltd has been specializing in the production of paclitaxel API for more than 20 years, and is one of the world’s independent manufacturers of paclitaxel API, a plant-derived anti-cancer drug, approved by the US FDA, European EDQM, Australian TGA, Chinese CFDA, India, Japan and other national regulatory agencies. Hande can provide not only high-quality paclitaxel raw materials, but also technical upgrade services related to paclitaxel formulation. For more information, please feel free to contact us at 18187887160.


Post time: Dec-15-2022