How does paclitaxel fight cancer?

Paclitaxel is a diterpenoid extracted from the Taxus genus Taxus, and scientists have found that it has strong antitumor activity in screening experiments. At present, paclitaxel is widely used in the treatment of breast cancer, ovarian cancer, non-small cell lung cancer, pancreatic cancer, esophageal cancer, gastric cancer, head and neck tumor, soft tissue sarcoma and other malignant tumors, and it is one of the most frequently used chemotherapy drugs in clinical practice. So how exactly does paclitaxel fight cancer? Let’s take a look below.

How does paclitaxel fight cancer?

How does paclitaxel fight cancer? It is well known that during normal cell division, the cell is divided into two parts. After the chromosome is replicated, the spindle filament pulls it from its original position to both sides, and the spindle needs the depolymerization of microtubules as the cytoskeleton to form, Chromosomes can only complete mitosis by moving to the poles under the traction of the spindle and the spindle filament, so microtubules are very important in cell division.

In 1979, the pharmacologist Horwitz discovered that paclitaxel can bind to tubulin and promote the polymerization of tubulin to form microtubules, thereby inhibiting the normal physiological disaggregation of microtubules, making it unable to form spindles and spindle filaments, making cells The inability to divide normally prevents the rapid reproduction of cancer cells and induces apoptosis of cancer cells. Therefore, among anticancer drugs, paclitaxel is regarded as a microtubule inhibitor in mitosis.

Note: The potential efficacy and applications described in this article are derived from the published literature.

paclitaxel API

Extended reading:Yunnan Hande Biotechnology Co., Ltd. has been focusing on the production of paclitaxel for 28 years. It is the world’s first independent manufacturer of the plant-derived anticancer drug paclitaxel that has been approved by the US FDA, European EDQM, Australian TGA, China CFDA, India, Japan and other national regulatory agencies. enterprise. If you want to buy Paclitaxel API, please contact us online.


Post time: Sep-30-2022