Natural Paclitaxel VS Semi-synthetic Paclitaxel (I)

Device Medication

Paclitaxel,as an anticancer drug,is widely used in various Injections and Devices.

It is mainly made by natural extraction and synthesis.

Natural Paclitaxel VS Semi-synthetic Paclitaxel (I)

As the plant source of naturally extracted paclitaxel,Taxus Chinensis,is relatively scarce and has a long growth cycle,a series of synthesis methods have been slowly derived from paclitaxel through research and experiments around the world,including total synthesis,semi-synthesis,and endophytic synthesis.

Due to the long chemical synthesis path,many synthesis steps,and difficult to control the reaction conditions,the fully synthesized paclitaxel needs to use more expensive chemical reagents,and the yield is also low,which is not suitable for mass production and industrial production in general.

Therefore,the relatively large amount of paclitaxel in the market is generally made by natural extraction of cultivated taxus and semi-synthetic methods.

Natural Paclitaxel vs Semi-synthetic Paclitaxel

Part 1:Production Process

Natural paclitaxel:

-Raw material:Artificially planted Yew

-Extraction process:raw material+column chromatography+recrystallization=finished product

-Extraction process:physical reaction,no chemical synthesis process

Semi-synthetic Paclitaxel:

-Raw material:Artificially planted Yew

-Extraction process:raw material+chemical reagent reaction+concentrated crystallization+various chemical reactions+recrystallization=finished product

-Extraction process:chemical reaction

In terms of technology,natural paclitaxel has simpler extraction steps compared with semi-synthetic paclitaxel and more advantages over semi-synthetic paclitaxel in terms of stability and safety,while semi-synthetic paclitaxel reduces the cost of product development in terms of cost and raw materials,and also improves some problems caused by the scarcity of raw materials on the market.

Compared with the two methods of producing paclitaxel,natural paclitaxel has better stability and safety in medical devices,which is one reason why most medical device companies in the market use natural paclitaxel as raw material.

Yunnan Hande Biotechnology Co.,Ltd.has been engaged in the extraction and development of taxanes for 30 years,and its core products are natural paclitaxel,10-DAB semi-synthetic paclitaxel,10-deacetylbaccatin III,docetaxel,cabazitaxel,etc.For more information about paclitaxel APIs,please contact us!!!(Whatsapp/Wechat:+86 18187887160)


Post time: Jan-17-2023