Yew taxus chinensis extract is extracted from natural scarce plants,laid,stem,skin,root contains the main ingredients are:yew alkali diterpenoid compounds,yew ning A and yew,yew ning H,yew,yew ning K,l,yew alkali,jinsong yellow ketone,slope that leave A,this leave ketone ketone,jinsong double yellow ketone,naphtha,yew,polysaccharide,tannins,tanned red,etc.,can also contain other polyphenols,amino acids,wood resin,inorganic elements.Paclitaxel has anti-leukemia and tumor effects.
Paclitaxel,which we are going to talk about,is the most excellent natural anti-cancer drug that has been found so far.It has been widely used in the treatment of breast cancer,ovarian cancer,head and neck cancer,lung cancer and many other cancers clinically.
Natural Paclitaxel vs Semi-synthetic Paclitaxel
Impurities:
Natural paclitaxel is extracted from the roots,stems and leaves of Taxus chinensis.After column chromatography and recrystallization,the whole process is physical extraction and purification without chemical reaction.The impurities contained in it are from the ingredients of the plant itself,and there are no impurities brought in by chemical synthesis.Therefore,the impurity fixation of natural paclitaxel is more fully studied and more controllable at present.
Semi-synthetic paclitaxel has more chemical synthesis than natural ones in its process,and its impurity sources are also more than natural ones,including some extracted from plants,and some impurities generated from chemical synthesis reaction.In addition,the chemical reaction will also cause the emergence of some potential impurities.In this process,the quantity and type of impurities are constantly changing.Therefore,semi-synthetic paclitaxel has low controllability in impurities,and new impurities need to be constantly studied in the production process.Impurities produced by different production processes are also very different,and specific analysis is required.
Yunnan Hande Bio-Tech has been engaged in the extraction and development of taxanes for 30 years,and its core products are natural paclitaxel,10-DAB semi-synthetic paclitaxel,10-deacetylbaccatin III,docetaxel,cabazitaxel,etc.For more information about paclitaxel APIs,please contact us!!!(Whatsapp/Wechat:+86 18187887160)
Post time: Jan-19-2023