The efficacy and role of paclitaxel

Paclitaxel comes from Taxus chinensis and is the earliest substance found to have an inhibitory effect on tumor cells. The structure of paclitaxel is complex, and its medical applications are mainly manifested in the treatment of breast cancer, lung cancer, and ovarian cancer. Paclitaxel is a secondary metabolite extracted from the bark of Taxus chinensis by American chemists, which has a good anti-tumor effect. Let’s take a look at the efficacy and role of paclitaxel.

The efficacy and role of paclitaxel

1. Anti-tumor effect

Paclitaxel is an anti-microtubule antitumor drug. Paclitaxel can promote microtubule assembly by promoting the polymerization of spinosomal tubulin subunits, even in mediators required for normal microtubule assembly (such as GTP, guanosine triphosphate, etc.). , etc.) can also have this effect, resulting in the formation of nonfunctional, stable microtubules.

2. Anti-cancer effect

Paclitaxel has anticancer effects on malignant sarcoma cell lines, leukemia and malignant melanoma. Paclitaxel is also a first-line drug for women with advanced breast and ovarian cancer. Paclitaxel can bind to microtubules, which can “freeze” and prevent the separation of chromosomes during cell division, which can rapidly kill cancer cells.

3. Treatment of rheumatoid arthritis

Studies have shown that paclitaxel has been approved by the FDA for the treatment of rheumatoid arthritis, and paclitaxel gel is a topical formulation of paclitaxel for the treatment of rheumatoid arthritis.

Note: The potential efficacy and applications described in this article are derived from the published literature.

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