What are the advantages of paclitaxel polymer micelles?

We know that the varieties of paclitaxel that have been marketed include paclitaxel injection, liposomal paclitaxel, docetaxel, and albumin-bound paclitaxel. What are the advantages of the newly marketed paclitaxel and paclitaxel polymer micelles? Let’s take a look at the following.

What are the advantages of paclitaxel polymer micelles?

Advantages of paclitaxel polymer micelles

1. The copolymer is self-assembled in water to form a nanocarrier with a”core-shell” structure. The nuclear encapsulated paclitaxel of the micelle is not degraded, so that it can play a role in the blood for a longer time

2. The polymer micellar paclitaxel particles are very small(18-20nm), which can be passively targeted into the tumor microenvironment with vascular disorders. In this way, the drug is more likely to stay in tumor tissue, resulting in its high concentration in tumor tissue and low concentration in normal tissue. While improving the efficacy, the incidence of side effects is further reduced.

Application of paclitaxel polymer micelles in china

In October 2021, China National Drug Administration(NMPA)announced that the first paclitaxel polymer micelle in China had been approved,and the indication was non-small cell lung cancer.

Note: The potential efficacy and applications introduced in this article are all from published literature.

Yunnan Hande Biotechnology Co., Ltd has been specializing in the production of paclitaxel API for more than 20 years, and is one of the world’s independent manufacturers of paclitaxel API, a plant-derived anti-cancer drug, approved by the US FDA, European EDQM, Australian TGA, Chinese CFDA, India, Japan and other national regulatory agencies. Hande can provide not only high-quality paclitaxel raw materials, but also technical upgrade services related to paclitaxel formulation. For more information, please feel free to contact us at 18187887160.


Post time: Dec-15-2022