Sophora flavescens extract Sophoridine 98% cosmetic raw materials

Short Description:

Sophora flavescens extract is the extract of Sophora flavescens, a leguminous plant. The content of oxymatrine, the main effective component, is more than 98%. It has the functions and abilities of clearing heat, drying dampness, killing insects and diuresis. It is used for hot dysentery, bloody stool, jaundice, urinary closure, red leucorrhea, Yin swelling, Yin itching, eczema, wet sore, skin pruritus, scabies, leprosy, external treatment of trichomonal vaginitis.


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Sophora flavescens extract is the extract of Sophora flavescens, a leguminous plant. The content of oxymatrine, the main effective component, is more than 98%. It has the functions and abilities of clearing heat, drying dampness, killing insects and diuresis. It is used for hot dysentery, bloody stool, jaundice, urinary closure, red leucorrhea, Yin swelling, Yin itching, eczema, wet sore, skin pruritus, scabies, leprosy, external treatment of trichomonal vaginitis.
1、 Main components
Sophora flavescens extract mainly contains a variety of alkaloids and flavonoids. The alkaloids are mainly matrine and Oxymatrine, as well as dehydro matrine, d-sophoricine, 1-smelly bean base, 1-methylgenistein, 1-wild indigo leaf base, 1-sophora root base, etc. Flavonoids include matrine, hypomatrine, sophoroside, isodehydrated icariin and so on.
2、 Function
1. Protection of gastric mucosa
Sophora flavescens extract has obvious protective effect on gastric mucosal injury caused by hydrochloric acid, ethanol and indomethacin. Its main component is flavanone compounds.
2. Anti inflammatory effect
Matrine has obvious anti-inflammatory effect on acute exudative inflammation caused by various inflammatory agents (croton oil, glacial acetic acid, carrageenan and egg white), which is similar to that of hydrocortisone. Studies have shown that this product has the characteristics of non steroidal anti-inflammatory drugs. In addition, matrine has a stabilizing effect on erythrocyte membrane, and drugs that have a stabilizing effect on erythrocyte often have a stabilizing effect on lysosomal membrane, so as to reduce the release of inflammatory mediators and achieve the purpose of anti-inflammatory.
3. Antitumor effect
Sophocarpine also has anticancer activity. Matrine, Oxymatrine, sophocarpine and their mixed a, B and C bases in different proportions had different inhibitory effects on S180 solid tumor. Matrine has a significant inhibitory effect on the colony production rate of peripheral multidirectional hematopoietic progenitor cells in chronic myeloid leukemia. Sophora flavescens decoction can significantly induce leukemia cells to differentiate into monocyte macrophages when it acts on human promyelocytic leukemia cells in vitro.
4. Leukocyte raising effect
Oxymatrine can prevent leukopenia in mice caused by MMC and cyclophosphamide. Intravenous or intramuscular injection of total Oxymatrine and Oxymatrine can significantly increase the number of peripheral blood leukocytes in normal rabbits. Moreover, the significant effect time, maintenance time and peak value of leukocyte count of oxymatrine on normal rabbits are basically the same within 18 days after administration, The whitening effect is better than that of shark liver alcohol.
5. Effect on cardiovascular system
Intravenous injection of matrine and Oxymatrine significantly antagonized arrhythmias induced by aconitine and chloroform adrenaline in rats; Intraperitoneal injection significantly antagonized and chloroform induced ventricular fibrillation in mice, increased the dosage of aconitine induced arrhythmia in rats, and antagonized arrhythmia induced by barium chloride and ligation of anterior descending coronary artery in rats.
6. Antiasthmatic and expectorant effect
Matrine is mainly through excitement β Receptors, especially the excitatory center β Receptor, relieving bronchospasm and inhibiting the release of antibodies and slow reactive substances.
7. Stabilizing effect
Matrine could significantly inhibit the free movement of mice; It significantly inhibited the passive activity of mice; High dose can inhibit the fighting and aggressive behavior of lonely mice.
8. Antifungal effect
Sophora flavescens decoction has inhibitory effect on common skin fungi.
9. Bacteriostasis
Sophora flavescens extract can inhibit Staphylococcus, Pseudomonas aeruginosa and Mycobacterium tuberculosis.
10. Effect on central nervous system
When matrine was injected into rabbits, central nerve paralysis was found, spasm occurred at the same time, and finally breathing stopped and died. When injected into the frog, it is initially excited, then paralyzed, and the breathing becomes slow and irregular. Later, spasm occurs, resulting in respiratory arrest and death. The attack of spasm is probably caused by hyperreflexia of spinal cord.
11. Antiarrhythmic effect
Sophora flavescens has a good antagonistic effect on arrhythmia caused by aconitine, sympathetic amine and digitalis poisoning, and its effect is quite similar to quinidine. That is, by affecting the potassium and sodium conduction system of cardiomyocyte membrane, the absolute refractory period of myocardium is prolonged and the stress is reduced, so as to inhibit ectopic pacemaker and play an anti arrhythmia role. The active ingredient was initially proved to be the alkaloid part. Because Sophora flavescens has no effect on myocardial contractility and heart rate of frog heart in vivo and rats, it does not increase myocardial oxygen consumption and aggravate heart failure and shock, which is worthy of attention for ischemic heart disease.
3、 Application field
1. Pharmaceutical industry: used for hot dysentery, bloody stool, jaundice, dysuria, red leucorrhea, Yin swelling and Yin itching, eczema, wet sore, skin itching, scabies, leprosy, external treatment of trichomonal vaginitis.
2. Cosmetics industry: Sophora flavescens extract has whitening, anti-inflammatory, anti acne, antibacterial and other effects. It has been used in beauty and skin care as early as hundreds of years ago. Now it is a favorite cosmetic raw material for major cosmetics.

Product Parameters

COMPANY PROFILE
Product Name Sophora flavescens extract
CAS N/A
Chemical Formula N/A
Main Products Matrine,Picfeltarraenin IV,Kurarinone,Kushenol A,Oxysophocarpine,Oxymatrine,Isokurarinone
Brand Hande
Manufacturer Yunnan Hande Bio-Tech Co., Ltd.
Country Kunming, China
Established 1993
 BASIC INFORMATION
Synonyms Matrine P.E;Sophira Flarescens Ait;Radix Flavescentis extract;Radix Sophorae Flavescentis;Bitter Sophora Root Extract;Extract of sophora flavescens;Flavescens Extract;Sophorae Flavescentis RadixE
Structure N/A
Weight N/A
HS Code N/A
Quality Specification Company Specification
Certificates N/A
Assay Customized according to customer needs
Appearance White acicular crystal or crystalline powder
Method of Extraction Sophora flavescens
Annual Capability Customized according to customer needs
Package Customized according to customer needs
Test Method HPLC
Logistics Multiple transports
Payment Terms T/T, D/P, D/A
Other Accept customer audit all the time; Assist clients with regulatory registration.

 

Hande product statement

1.All products sold by the company are semi-finished raw materials. The products are mainly aimed at manufacturers with production qualifications, and raw materials are not final products.
2.The potential efficacy and applications involved in the introduction are all from the published literature. Individuals do not recommend direct use, and individual purchases are refused.
3.The pictures and product information on this website are for reference only, and the actual product shall prevail.


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