CAS 114977-28-5 Taxus chinensis extract Pharmaceutical API

Product Informations

CAS 114977-28-5 has good curative effect on advanced breast cancer,ovarian cancer and non-small cell lung cancer.It also has certain curative effects on head and neck cancer,pancreatic cancer,small cell lung cancer,gastric cancer,melanoma,and soft tissue sarcoma.
Established in 1993,Yunnan Hande bio-tech Co.,Ltd.is a leading CAS 114977-28-5 API manufacturer with a great fame over the world,the company located at Kunming,Yunnan,P.R.China,owned China GMP certificate,CEP,and approved by US FDA and TGA,also entered U.K,India,Japan,Canada,Singapore,South Korea,Taiwan China,Malaysia,Russia,Turkey and Zimbabwe,in the records.
The new manufacture base covers an area of 20 acres with over 10,000 square meters of factory buildings.Equipment includes the international standard testing room,covering liquid,gas,metal elements,infrared,microbes,moisture determination,All inspection items such as stability inspection,using all-in-one testing equipment,complete data integrity IT system,efficient&fully enclosed separation and purification production line,and clean factory buildings.
CAS 114977-28-5 is a taxane drug,which inhibits the growth of cancer cells by promoting the assembly of microtubule dimers into microtubules,and at the same time,it stabilizes microtubules by preventing the process of demultimerization,and blocks cells in G2 and M phases.Mitosis and proliferation.The pharmacological effect of CAS 114977-28-5 is stronger than that of paclitaxel,its intracellular concentration is 3 times higher than that of paclitaxel,and its intracellular retention time is longer,and its affinity for microtubules is 2 times that of paclitaxel;as a microtubule stabilizer and assembly promoter,The activity is 2 times greater than that of paclitaxel;as a microtubule depolymerization inhibitor,the activity is 2 times greater than that of paclitaxel.

 Product Parameters

COMPANY PROFILE
Product Name	CAS 114977-28-5
CAS	114977-28-5
Chemical Formula	C43H53NO14
Brand	Hande
Manufacturer	Yunnan Hande Bio-Tech Co., Ltd.
Country	Kunming, China
Established	1993
BASIC INFORMATION
Synonyms	(2AR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-;TXD-258;(αR,βS)-β-[[(1,1-DiMethylethoxy)carbonyl]aMino]-α-hydroxybenzenepropanoicAcid(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxyChemicalbook)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-diMethoxy-4a,8,13,13-tetraMethyl-5-oxo-7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-ylEster;XRP6258;Cabazitaxel;XRP6258;RPR-116258A;TAXOIDXRP6258;TXD258;CS-877;Cabazitaxel183133-96-2
Structure
Weight	807.88
HS Code	N/A
Quality Specification	Company Specification
Certificates	N/A
Assay	Customized according to customer needs
Appearance	white powder
Method of Extraction	10-DAB semi-synthesis
Annual Capability	Customized according to customer needs
Package	Customized according to customer needs
Test Method	HPLC
Logistics	Multiple transports
Payment Terms	T/T, D/P, D/A
Other	Accept customer audit all the time; Assist clients with regulatory registration.