Natural paclitaxel and 10-DAB semi synthetic paclitaxel are two different types of paclitaxel,with slightly different sources and preparation methods.
Natural paclitaxel is a high-purity substance obtained by purifying a natural compound extracted from the bark of yew trees.Taxus chinensis is a slow growing tree species,so the production of natural paclitaxel is very limited and the price is relatively high.
10-DAB semi synthetic paclitaxel is prepared by chemical synthesis methods.It is synthesized through a series of chemical reactions based on an intermediate called 10-DAB(10-deacetylbacardine).10-DAB can be extracted from the bark of yew trees or produced through microbial fermentation.The preparation process of semi synthetic paclitaxel uses more raw materials and solvents,so the cost is relatively low and the yield is also relatively large.
Both natural paclitaxel and 10-DAB semi synthetic paclitaxel have similar chemical structures and pharmacological effects,namely inhibiting microtubule protein polymerization,disrupting tumor cell mitosis,and leading to tumor cell death.Therefore,they have similar therapeutic effects and uses in the treatment of cancer.However,due to their different sources and preparation methods,there are also differences in their purity,impurity content,and cost.When choosing to use natural paclitaxel or 10-DAB semi synthetic paclitaxel,it is necessary to evaluate and make decisions based on specific circumstances.
Explanation:The potential benefits and applications mentioned in this article are all from publicly available literature.
Post time: Jan-15-2024