Paclitaxel is a substance extracted from yew,which can effectively inhibit cancer and is a widely used star anticancer drug in the world.In the 1960s,American chemists isolated taxol from the bark of Pacific yew,a Taxus plant.After more than 20 years of clinical research,the first paclitaxel injection”Taxol”was launched in 1992.Up to now,paclitaxel is one of the known botanical anti-tumor drugs with good efficacy.It has the characteristics of high efficiency,low toxicity and broad spectrum.It has obvious therapeutic effects on ovarian cancer,breast cancer,malignant Melanoma,lung cancer,prostate cancer,brain cancer and colorectal cancer.
The results of medical experiments show that,at present,the acquisition of paclitaxel APIs mainly depends on the extraction of Taxus chinensis plants and chemical Semisynthesis.Scientific researchers collect artificially cultivated branches and leaves of Taxus chinensis chinensis,use solvent extraction,solid phase extraction,Supercritical fluid extraction,membrane separation,chromatographic separation and other separation and extraction methods to extract precursors similar to the structure of paclitaxel,such as bacatine III,10 deacetyl bacatine III,etc.,and then obtain medical paclitaxel bulk drugs by chemical modification of mass production methods.
According to scientists’calculations,cancer patients need to consume more than 2 grams of paclitaxel in a single course of treatment.These traces of paclitaxel need to be extracted from the bark of 4-8 wild Taxus chinensis trees that have grown for more than 50 years.On the one hand,Taxus chinensis and paclitaxel are scarce,and on the other hand,there is a huge medical demand,which leads to the high price of Taxus chinensis raw materials all the year round,and the supply falls short of demand.
Explanation:The potential efficacy and applications mentioned in this article are all from publicly available literature.
Extended reading:Yunnan Hande Bio-tech is mainly engaged in the extraction and development of taxanes.Its core products are natural Paclitaxel,10-DAB Semisynthesis Paclitaxel,10-DABIII,docetaxel,cabataxel,etc.If you need to know about paclitaxel based raw materials,please feel free to contact us at.
Post time: Jun-14-2023