Epigallocatechin gallate, or EGCG, with the molecular formula c22h18o11, is the main component of green tea polyphenols and a catechin monomer isolated from tea.
Catechins are the main functional components in tea, accounting for 12% – 24% of the dry weight of tea. The catechins in tea mainly include catechin (c), epicatechin (EC), gallicatechin (GC), epigallocatechin (EGC), catechin gallate (CG), epicatechin gallate (ECG) There are 8 monomers of gallatechin gallate (GCG) and epigallocatechin gallate (EGCG).
Epigallocatechin gallate is α- The ester formed by bisphenol benzopyran and gallic acid has the generality of phenolic oxidation resistance. Its molecular structure has 6 ortho phenolic hydroxyl groups, so it has many properties superior to other catechins. It has antibacterial, anti-inflammatory, antioxidant and anti mutation effects, and can also be used as a reversal agent of tumor multidrug resistance. It can improve the sensitivity of cancer cells to chemotherapy, reduce the toxicity to the heart, and protect the endothelium. It can effectively promote vasodilation and reduce the occurrence of cardiovascular diseases.
Compared with tea polyphenol extract, high-purity epigallocatechin gallate has the advantages of clear active ingredients, no interference of impurities and side effects, and stronger activity. Therefore, the separation and purification of epigallocatechin gallate is of great significance. At present, the main separation methods of epigallocatechin gallate mainly include HPLC separation, glucose gel separation, supercritical fluid extraction, column chromatography and so on. Because the adsorption filler is cheap, it has the advantages of strong adsorption capacity, easy desorption, high stability, renewable, repeated use and so on.
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Post time: Jul-08-2022