Paclitaxel is an excellent natural anti-cancer drug that has been found at present.It is widely used in clinical treatment of ovarian cancer,breast cancer,lung cancer,head and neck tumors,esophageal cancer,gastric cancer and soft tissue sarcoma.Paclitaxel has attracted great interest from scientists due to its complex and novel chemical structure,unique biological mechanisms of action,reliable anticancer activity,and severe resource scarcity.According to statistics,more than 30 top laboratories around the world have been engaged in the research of Total synthesis of paclitaxel,and the competition is very fierce,which has become the focus of organic synthetic chemistry in the late 20th century.
The unique anti-tumor mechanism of paclitaxel
Paclitaxel can make Tubulin and Tubulin dimer that make up microtubules lose Dynamic equilibrium,induce and promote Tubulin polymerization,microtubule assembly,and prevent depolymerization,so as to stabilize microtubules and inhibit Mitosis of cancer cells and trigger apoptosis,thereby effectively preventing the proliferation of cancer cells and playing an anti-cancer role.
In fact,Tubulin,which is closely related to cell Mitosis,exists almost universally in all eukaryotic cells.They can polymerize into microtubules reversibly.Chromosome separation requires the help of these microtubules.After Mitosis,these microtubules are again depolymerized into Tubulin.The temporary disintegration of hammer like microtubules can preferentially kill the cells with abnormal division.Some important anti-cancer drugs,such as colchicine,Vinblastine,Vincristine,play an anti-tumor role by preventing Tubulin from re polymerization.
Contrary to anti Mitosis and anti-tumor drugs,paclitaxel is the first drug found that can interact with Tubulin polymer,that is,it works by closely combining with microtubules to make them stable.At the same time,it is found that paclitaxel shows good effects on a variety of solid tumor cells.This new discovery has attracted more biologists to use paclitaxel as a research tool in biomedicine,exploring unknown fields of cell activity and discovering new methods for anticancer drugs.
Explanation:The potential efficacy and applications mentioned in this article are all from publicly available literature.
Yunnan Hande Bio-tech has been focusing on the production of paclitaxel for 28 years. It is an independent production enterprise of paclitaxel raw materials, which has been approved by national regulatory agencies such as the FDA in the United States, EDQM in Europe, TGA in Australia, CFDA in China, India, and Japan. Yunnan Hande paclitaxel is available in stock and sold directly by manufacturers. Welcome to inquire.
Post time: Jun-12-2023