Paclitaxel,also known as red paclitaxel,tamsulosin,violet,and tesu,is the best natural anti-cancer drug discovered so far,and has been widely used in the clinical treatment of breast cancer,ovarian cancer,and some head and neck cancers and lung cancer.As a classical chemotherapy drug,the name of paclitaxel is believed that many people have heard of it.Let’s take a look at the differences between the four types of paclitaxel in the following article.
The difference between the four types of paclitaxel
1、Paclitaxel:It acts on microtubule/microtubule protein system,inhibits microtubule depolymerization,blocks cell cycle in G2/M phase,leads to abnormal mitosis or arrest,prevents tumor cell replication,and makes cancer cells unable to continue to divide and die.
2、Docetaxel:The mechanism of action is the same as that of paclitaxel,but with higher affinity to microtubule binding site and higher anti-cancer activity.
3、Liposomal paclitaxel:The mechanism of action is the same as that of paclitaxel.The liposomes composed of lecithin,cholesterol,threonine and other materials similar to the phospholipid bilayer structure of cell membranes encapsulate paclitaxel,which can improve water solubility,penetrate more easily into tumor tissues from blood vessels,and reduce the toxicity of heart and kidney,etc.
4.Albumin-bound paclitaxel:hydrophobic paclitaxel is combined with human serum albumin carrier by nanotechnology.Albumin can increase the uptake of paclitaxel in tumor by binding to gp60 receptor and increase the concentration of paclitaxel in tumor tissue,thus increasing the anti-tumor effect.
Both paclitaxel,doxorubicin,paclitaxel liposome or albumin paclitaxel are the same type of chemotherapeutic drugs,and all belong to the paclitaxel class in the classification of chemotherapeutic drugs.They are the same type of drug.Paclitaxel is an antitumor drug with the principle of microtubule inhibitor,which is widely used in breast cancer chemotherapy.
Note:The potential efficacy and applications covered in this presentation are derived from published literature.
Extended reading:Yunnan Hande Biotechnology Co., Ltd. has been focusing on the production of paclitaxel for 28 years. It is the world’s first independent manufacturer of the plant-derived anticancer drug paclitaxel that has been approved by the US FDA, European EDQM, Australian TGA, China CFDA, India, Japan and other national regulatory agencies. enterprise. If you want to buy Paclitaxel API, please contact us online.
Post time: Oct-08-2022