What are paclitaxel,paclitaxel for injectable suspension and albumin-bound paclitaxel?What are the main uses?We will briefly describe them in this article.
A natural secondary metabolite isolated and purified from the bark,branches and leaves of the gymnospermous taxus chinensis can promote microtubule polymerization and stabilize the polymerized microtubules.Cells exposed to paclitaxel will accumulate a large number of microtubules in the cells.The accumulation of these microtubules interferes with various functions of the cells,especially stopping the cell division at the mitotic stage,and blocks the normal cell division.
It has a good anti-tumor effect and is used to treat advanced breast cancer,lung cancer,ovarian cancer,head and neck cancer,soft tissue cancer and digestive tract cancer.
Paclitaxel(Taxol)is an anticancer API(Active Pharmaceutical Ingredient),which cannot be directly used by people.It needs to be supplied to downstream companies or pharmaceutical factories to become one of the API of finished drugs.
At present,the most widely used of paclitaxel is anticancer injections and medical devices(including stents and balloons).With the rapid development of biotechnology and medical technology,the use of paclitaxel is also constantly being explored,and the different conditions of patients are also continuously improved.Believe that in the near future,it will be safer and more conducive to the treatment of doctors and patients,and there will be more and more varieties of anticancer drugs containing paclitaxel with stronger anticancer effect.
Paclitaxel for Injectable Suspension:
An injection containing paclitaxel API.
Paclitaxel for injection also includes polyoxyethylene castor oil paclitaxel injection;Liposome paclitaxel injection;Albumin bound paclitaxel injection;Micellar paclitaxel and other dosage forms.
It is widely used in breast cancer,lung cancer,ovarian cancer and other diseases,and is one of the most effective anticancer drugs at present.
Albumin Bound Paclitaxel:
Albumin bound paclitaxel injection is a preparation combining paclitaxel and albumin.It belongs to paclitaxel for injection and is one of the most widely used paclitaxel injections with high safety.
Albumin paclitaxel,the first to enter people’s eyes is ABRAXANE Injection(ABRAXANE For Injectable Suspension paclitaxel protein-bound particles for injectable suspension,albumin-bound)approved by FDA in 2005,which is used to treat metastatic breast cancer.Its average particle size after re-dissolution is about 130 nm,and it does not contain toxic solvents.Its safety effect and therapeutic effect are much higher than that of similar preparations,and it is extremely popular.It is also one of the main reasons for the research and imitation of major pharmaceutical enterprises in the future.
It is mainly applicable to the treatment of metastatic breast cancer that fails in combined chemotherapy or breast cancer that relapses within 6 months after adjuvant chemotherapy.
Yunnan Hande Bio-Tech is committed to the research&development and production of paclitaxel,docetaxel,10-DAB semi-synthetic paclitaxel,and cabazitaxel,and has detailed data research on various impurities contained in paclitaxel.In addition,Hande also provides technology transfer services related to paclitaxel:traditional paclitaxel injections;Albumin bound paclitaxel injections etc,welcome to contact us to inquire!（Whatsapp/Wechat：+86 18187887160）
Post time: Feb-09-2023