Glabridin originates from the plant Glycyrrhiza glabra,only exists in the root and stem of Glycyrrhiza glabra(Eurasia),and is the main Isoflavone component of Glycyrrhiza glabra.Glabridin has whitening,antioxidant,anti-inflammatory and other effects.Due to the relatively low content of glabridin and the difficulty of purification process,it has the title of”whitening gold”.
1、The whitening principle of Glabridin
Before understanding the whitening principle of glabridin,we need to first briefly understand the causes of melanin production.
The synthesis of melanin requires three basic substances:
Tyrosine:The main raw material for producing melanin.
Tyrosinase:the main rate limiting enzyme that converts tyrosine into melanin.
Reactive oxygen species:Tyrosine must be combined with oxygen in the process of producing melanin under the action of Tyrosinase.
Tyrosinase can produce melanin regularly.External stimuli(including common ultraviolet rays,inflammation,allergies,etc.)can lead to excessive secretion,leading to blackening.
At the same time,reactive oxygen species(ROS)induced by ultraviolet radiation can damage the phospholipid membrane of skin tissue,manifested as erythema and pigmentation on the skin.Therefore,ROS is a substance that can cause pigmentation on the skin.Therefore,inhibiting its generation can inhibit the generation of melanin and pigmentation.
2、The whitening advantages of Glabridin
In short,the process of whitening and spot lightening is the process of fighting against Tyrosinase and reactive oxygen species.
Glabridin mainly inhibits the activity of Tyrosinase through competitive Sexual inhibition,taking part of Tyrosinase away from the catalytic ring of melanin synthesis,preventing the combination of substrate and Tyrosinase,thus inhibiting the synthesis of melanin.At the same time,glabridin itself has good antioxidant and anti-inflammatory effects.
To sum up,glabridin mainly inhibits melanogenesis through three directions:inhibiting the activity of Tyrosinase,inhibiting the generation of reactive oxygen species,and inhibiting inflammation.
Experiments have shown that it is a fast,efficient,and green whitening and freckle removing cosmetic additive.There is experimental data indicating that the whitening effect of Glabridin is 232 times that of ordinary vitamin C,16 times higher than hydroquinone(quinone),and 1164 times that of”arbutin”.
Explanation:The potential efficacy and applications mentioned in this article are all from publicly available literature.
Post time: Jun-28-2023