Chemical structure and name:
INCI name:Troxerutin/Troxerutin
Nickname:Vitamin P4,Trihydroxyethyl Rutin
CAS No:7085-55-4
Molecular weight:742.7 g/mol
Molecular formula:C33H42019
Product characteristics
The"Catalogue of Names of Used Cosmetic Raw Materials(2015 Edition)"released by the National Drug Administration includes troxerutin in this catalog with serial number 05450.
1 Biological activity on capillaries
Troxerutin can inhibit the aggregation of red blood cells and platelets,increase the vascular resistance of small arteries,inhibit the increase of capillary permeability and reduce the abnormal blood seepage of capillaries,prevent thrombosis,improve microcirculation,increase the oxygen content in blood,promote the formation of new blood vessels to improve the circulation of side chains,etc.Therefore,it is commonly used in clinical practice to treat cerebral thrombosis,thrombophlebitis,and capillary bleeding.
2 Effectively absorb ultraviolet and resist blue light
UV irradiation can cause skin damage,skin discoloration,and skin aging,and the impact of blue light(400nm~500nm)in visible light on the skin cannot be ignored.The penetration of blue light to the skin is stronger than UVA,reaching the dermis,disturbing the circadian rhythm of the skin,accelerating skin photoaging and causing skin pigmentation.Troxerutin can effectively block ultraviolet and blue light from 380nm to 450nm,and the effective concentration can be as low as 0.025%.
3 Resistance to UV damage
(1)It can inhibit UVB induced apoptosis of HaCaT cells(human immortalized keratinocytes),inhibit MAPK signaling pathway transduction and transcription factors AP-1(c-Fos and c-Jun),and thus play a role in resisting light damage;
(2)The expression of miRNAs can be regulated to protect nHDFs(fibroblasts)from UV induced oxidative stress and DNA damage.
4 Antioxidant
Early studies have shown that troxerutin can inhibitγRadiation induced lipid peroxidation in subcellular organelle,cell membranes and normal tissues of tumor mice.
Troxerutin against hydroxyl radical and ABTS.+The elimination effect of free radicals is similar to that of VC,which may be related to the active phenolic hydroxyl groups on the aromatic ring.
5 Enhance skin barrier function
Troxerutin can regulate miR-181a to accelerate the differentiation of keratinocytes,consolidate the"brick wall structure"of the skin,and thus enhance the skin barrier function.The increased mRNA expression level of keratinocyte differentiation markers(such as keratin 1,keratin 10,skin protein,and filaggrin)confirmed that troxerutin can promote keratinocyte differentiation.
Product Application
The recommended dosage is 0.1-3.0%.
★Anti blue light products
★Red blood removal products
★Anti aging products
★Leg Cream
★Sunscreen products
★Products for removing dark circles under the eyes
★White products
★Repair products
Product prompt
Troxerutin is easily soluble in water and is stable to light and heat;It can be directly added after the system is below 45℃.
Product specifications
1kg/bag,25kg/barrel
Storage
Store in a cool,dry,and dark place,sealed for storage,and should be used as soon as possible after opening.Under recommended storage conditions,unopened products have a shelf life of 24 months.
