Natural paclitaxel is a complex secondary metabolite extracted from the bark of taxus chinensis.It is the only known drug that can promote microtubule polymerization and stabilize polymerized microtubules.After the cell contact with paclitaxel,a large number of microtubules will accumulate in the cell,and the accumulation of these microtubules interferes with various functions of the cell,especially the cell division stops in the mitosis period,blocking the normal division of the cell.
Natural paclitaxel has a wide range of medicinal value,it is considered to be a high efficiency,low toxicity,broad spectrum of natural anticancer drugs.Clinically,it is often used to treat malignant tumors such as breast cancer,ovarian cancer,uterine cancer,some head and neck cancer and lung cancer.Its mechanism of action is to prevent the polymerization and depolymerization of tubulin by binding to tubulin,thus inhibiting the mitosis of tumor cells and inducing apoptosis of tumor cells.In addition,paclitaxel can also regulate the activity of anti-apoptotic mediators.